Synthesis and Characterization of Ciprofloxacin-loaded Chitosan Nanoparticles for Eradication of Pseudomonas aeroginosa Biofilm

Background: Pseudomonas aeruginosa biofilm is one of the problems in antibiotic treatment infections. Nanomedicines, such as chitosan (CS) can carry multiple drugs and improve therapeutic effects antibiotics. Objectives: This study aimed at synthesis characterization ciprofloxacin-loaded nanoparticles for eradication P. aeroginosa biofilm. Methods: Cipro-CS microparticles were prepared by ionic gelation method their size, zeta potential, drug release pattern determined. MBEC MBIC different groups antibiotics (ciprofloxacin, ciprofloxacin-PAβN, CS ciprofloxacin, ciprofloxacin-PAβN) performed on samples aeroginosa. Results: Ciprofloxacin loading efficiency was 35.51%, encapsulation 55.06%. Released ciprofloxacin from 80% after 24 hours. Biofilm production positive 96.7% isolates while 30.1% had strong The best result ciprofloxacin- PAβN, respectively. For slightly to better Ciprofloxacin-PAβN, Ciprofloxacin, ciprofloxacin. Conclusion: Today, with increasing resistance, there are many challenges treating Due role researchers looking new treat